منابع مشابه
Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival.
The Kit receptor tyrosine kinase is required by vertebrate melanocytes for their migration and survival. The relationship between these developmental roles of Kit, however, remains poorly understood. Here, we use two genetic approaches to demonstrate that Kit's roles in the migration and survival of embryonic melanocytes in the zebrafish (Danio rerio) are temporally and functionally independent...
متن کاملGene Duplication of the Zebrafish kit ligand and Partitioning of Melanocyte Development Functions to kit ligand a
The retention of particular genes after the whole genome duplication in zebrafish has given insights into how genes may evolve through partitioning of ancestral functions. We examine the partitioning of expression patterns and functions of two zebrafish kit ligands, kit ligand a (kitla) and kit ligand b (kitlb), and discuss their possible coevolution with the duplicated zebrafish kit receptors ...
متن کاملLegacy Systems Migration : A Method and its Tool-Kit Framework
The problems posed by mission-critical legacy systems brittleness, inflexibility, isolation, non-extensibility, lack of openness etc. are well known, but practical solutions have been slow to emerge. Most approaches are “ad hoc” and tailored to peculiarities of individual systems. This paper presents an approach to mission-critical legacy system migration : the Butterfly Methodology, its data m...
متن کاملEctopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryos.
The Patch (Ph) mutation in the mouse, a deletion that includes the gene for PDGFR alpha, is a recessive lethal that exhibits a dominant pigment phenotype in heterozygotes. To assess whether the Ph mutation acts cell-autonomously or non-autonomously on melanocyte development, we have examined the melanogenic potential of neural crest populations from normal and mutant crest cells in vitro and th...
متن کاملKit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos.
Adult stem cells are crucial for growth, homeostasis and repair of adult animals. The melanocyte stem cell (MSC) and melanocyte regeneration is an attractive model for studying regulation of adult stem cells. The process of melanocyte regeneration can be divided into establishment of the MSC, recruitment of the MSC to produce committed daughter cells, and the proliferation, differentiation and ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2006
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5700164